Article
Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya.
PloS one - 1 Jan 2022
Ochwedo Kevin O, Onyango Shirley A, Omondi Collince J, Orondo Pauline W, Ondeto Benyl M, Lee Ming-Chieh, Atieli Harrysone E, Ogolla Sidney O, Githeko Andrew K, Otieno Antony C A, Mukabana Wolfgang R, Yan Guiyun, Zhong Daibin, Kazura James W
Abstract excerpt
BACKGROUND: Leading transmission-blocking vaccine candidates such as Plasmodium falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may render them ineffective or allele-specific. This study examines the level of genetic diversity, signature of selection and drivers of Pfs25 polymorphisms of parasites population in regions of western Kenya with varying malaria transmission...
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