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Article

Global diversity of the gene encoding the Pfs25 protein-a Plasmodium falciparum transmission-blocking vaccine candidate.

Parasites & vectors - 8 Nov 2021

Sookpongthai Pornpawee, Utayopas Korawich, Sitthiyotha Thassanai, Pengsakul Theerakamol, Kaewthamasorn Morakot, Wangkanont Kittikhun, Harnyuttanakorn Pongchai, Chunsrivirot Surasak, Pattaradilokrat Sittiporn

Abstract excerpt

BACKGROUND: Vaccines against the sexual stages of the malarial parasite Plasmodium falciparum are indispensable for controlling malaria and abrogating the spread of drug-resistant parasites. Pfs25, a surface antigen of the sexual stage of P. falciparum, is a leading candidate for transmission-blocking vaccine development. While clinical trials have reported that Pfs25-based vaccines are safe and effective in...

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Identifiers

PMID: 34749796
DOI: 10.1186/s13071-021-05078-6
PMCID: PMC8574928

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