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Article

Depression polygenic risk-linked multimodal MRI network and associated cognitive dysfunction.

Journal of affective disorders - 1 Nov 2026

Ma Yangrui, Tao Yuanmei, Amos Toluwani Joan, Yan Yushun, Wang Min, Liao Qimeng, Yang Xiao

Abstract excerpt

Major depressive disorder (MDD) involves complex genetic and neurobiological factors. This study integrated polygenic risk scores (PRS), neurocognitive assessments, and multimodal neuroimaging to examine relationships among genetic liability, brain alterations, and cognitive performance in MDD. A total of 74 patients with MDD and 70 healthy controls (HCs) underwent cognitive testing and MRI scans, with gray...

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PMID: 42225244
DOI: 10.1016/j.jad.2026.122061

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