Article
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 2014
Meda Shashwath A, Ruaño Gualberto, Windemuth Andreas, O'Neil Kasey, Berwise Clifton, Dunn Sabra M, Boccaccio Leah E, Narayanan Balaji, Kocherla Mohan, Sprooten Emma, Keshavan Matcheri S, Tamminga Carol A, Sweeney John A, Clementz Brett A, Calhoun Vince D, Pearlson Godfrey D
Abstract excerpt
The brain's default mode network (DMN) is highly heritable and is compromised in a variety of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and psychotic bipolar disorder (PBP) is largely unknown. Study subjects (n = 1,305) underwent a resting-state functional MRI scan and were analyzed by a two-stage approach. The initial analysis used independent component analysis (ICA) in...
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