Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System.

doi:10.1038/npp.2016.70

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Article

Investigating the Impact of a Genome-Wide Supported Bipolar Risk Variant of MAD1L1 on the Human Reward System.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2016

Trost Sarah, Diekhof Esther K, Mohr Holger, Vieker Henning, Krämer Bernd, Wolf Claudia, Keil Maria, Dechent Peter, Binder Elisabeth B, Gruber Oliver

Abstract excerpt

Recent genome-wide association studies have identified MAD1L1 (mitotic arrest deficient-like 1) as a susceptibility gene for bipolar disorder and schizophrenia. The minor allele of the single-nucleotide polymorphism (SNP) rs11764590 in MAD1L1 was associated with bipolar disorder. Both diseases, bipolar disorder and schizophrenia, are linked to functional alterations in the reward system. We aimed at investigating...

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PMID: 27184339
DOI: 10.1038/npp.2016.70
PMCID: PMC5026735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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