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Article

Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape.

Current neuropharmacology - 1 Jan 2017

Blum Kenneth, Febo Marcelo, Badgaiyan Rajendra D, Demetrovics Zsolt, Simpatico Thomas, Fahlke Claudia, M Oscar-Berman, Li Mona, Dushaj Kristina, Gold Mark S

Abstract excerpt

BACKGROUND: In 1990, Blum and associates provided the first confirmed genetic link between the DRD2 polymorphisms and alcoholism. This finding was based on an earlier conceptual framework, which served as a blueprint for their seminal genetic association discovery they termed "Brain Reward Cascade." These findings were followed by a new way of understanding all addictive behaviors (substance and non-substance)...

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Source

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Identifiers

PMID: 27174576
DOI: 10.2174/1570159x13666160512150918
PMCID: PMC5327445

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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