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Article

Acetylation Variability in Elderly Tunisians: Implications for Isoniazid Dose Individualization.

Journal of clinical pharmacology - 1 Jun 2026

Khefacha Yasmine, Ben-Hammamia Syrine, Ben Sassi Mouna, Ferchichi Khouloud, Daldoul Mouna, El Jebari Hanene, Zouari Mohamed, Salouage Issam, Charfi Rim, Daghfous Riadh, Gaies Emna, Trabelsi Sameh

Abstract excerpt

The relationship between age and isoniazid acetylation phenotype remains insufficiently characterized, particularly in elderly populations, where pharmacokinetic variability and susceptibility to toxicity may be increased. This study aimed to characterize isoniazid acetylation phenotypes in elderly Tunisian patients using a phenotypic index and to assess its clinical implications. A retrospective study was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antitubercular Agents

Share to Arylamine N-Acetyltransferase

Share to Dose-Response Relationship, Drug

Share to Isoniazid

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Source

Identifiers

PMID: 42223414
DOI: 10.1002/jcph.70217

Genes

C3
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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