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Advances in Visualizing Cytosine Methylation and Allele-Specific Epigenetic States in Tissue Context.

Pathology international - 1 Jun 2026

Kitazawa Sohei, Haraguchi Ryuma, Kitazawa Riko

Abstract excerpt

Epigenetic regulation represents a heritable, sequence-independent layer of transcriptional control that critically shapes tissue morphology throughout development, homeostasis, and disease. Although immunohistochemical detection of histone modifications is now well established in diagnostic pathology, direct visualization of DNA methylation-the central mechanism underlying transcriptional silencing, genomic...

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PMID: 42219791
DOI: 10.1111/pin.70133

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