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Article

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2026

Porter Tenielle, Armstrong Ayeisha Milligan, O'Brien Eleanor K, Doré Vincent, Bourgeat Pierrick, Turner Mitchell, Maruff Paul, Rowe Christopher C, Brown Belinda M, Villemagne Victor L, Rainey-Smith Stephanie R, Laws Simon M

Abstract excerpt

INTRODUCTION: Variants in the aquaporin-4 gene (AQP4) have been associated with Alzheimer's disease (AD) diagnosis, cognition, and brain amyloid beta (Aβ) and may affect the sleep and Aβ relationship. Their association with other AD-related phenotypes/disease progression remain largely unknown. METHODS: Associations between AQP4 variants, self-reported sleep measures, and AD-related phenotypes in cognitively...

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Identifiers

PMID: 42216479
DOI: 10.1002/alz.71516
PMCID: PMC13239059

Genes

AQP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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