Article
Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden.
Translational psychiatry - 26 Feb 2018
Rainey-Smith Stephanie R, Mazzucchelli Gavin N, Villemagne Victor L, Brown Belinda M, Porter Tenielle, Weinborn Michael, Bucks Romola S, Milicic Lidija, Sohrabi Hamid R, Taddei Kevin, Ames David, Maruff Paul, Masters Colin L, Rowe Christopher C, Salvado Olivier, Martins Ralph N, Laws Simon M
Abstract excerpt
The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid deposition, suggesting that Aquaporin-4 plays a pivotal role in glymphatic function. Currently there is a paucity of...
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