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Association of an Aquaporin-4 Haplotype With Cognition, Brain Volume, and Dementia Risk in Community-Dwelling Individuals Without Dementia.

Neurology - 14 Apr 2026

Palatsides Emma Louise, Himali Dibya, Cribb Lachlan, Peloso Gina M, Ryan Joanne, Yang Qiong, Decarli Charles S, Beiser Alexa S, Seshadri Sudha, Cavuoto Marina G, Yiallourou Stephanie, Baril Andrée-Ann, Himali Jayandra J, Pase Matthew Paul

Abstract excerpt

BACKGROUND AND OBJECTIVES: The aquaporin-4 (AQP4) water channel plays an integral role in clearing brain waste. However, little is known about whether variations in the AQP4 gene contributes to brain health or dementia risk. We aimed to determine whether a functional AQP4 haplotype was associated with cognition, brain volumes, or incident dementia. METHODS: This study included participants from 2 prospective...

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PMID: 41855452
DOI: 10.1212/WNL.0000000000214773

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AQP4

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