Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Real-time PCR-based intraoperative molecular boundary diagnosis of corticotroph pituitary neuroendocrine tumors.

Journal of neuroscience methods - 1 Oct 2026

Sato Yoshiki, Takeuchi Kazuhito, Ohka Fumiharu, Nagata Yuichi, Maeda Sachi, Matsuyama Tomoki, Hirose Toshiaki, Deguchi Shoichi, Okumura Eriko, Iwami Kenichiro, Saito Ryuta

Abstract excerpt

BACKGROUND: Corticotroph pituitary neuroendocrine tumors (PitNETs) causing Cushing's disease require complete surgical resection to achieve endocrinological remission. Although endoscopic transsphenoidal surgery is the standard first-line treatment, accurate intraoperative delineation of tumor boundaries remains challenging because the pseudocapsule is often thin or ill-defined and tumor cells may infiltrate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endopeptidases
Share to Endosomal Sorting Complexes Required for Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neuroendocrine Tumors

Share to Pituitary Neoplasms

Share to Real-Time Polymerase Chain Reaction

Share to Ubiquitin Thiolesterase

Source

Identifiers

PMID: 42214473
DOI: 10.1016/j.jneumeth.2026.110814

Genes

USP8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Real-time PCR-based intraoperative molecular boundary diagnosis of corticotroph pituitary neuroendocrine tumors.PMID 42214473Read ↗

Rapid intraoperative boundary diagnosis of somatotroph pituitary neuroendocrine tumors using real-time PCR.Semantic proximity Read ↗

USP8 Mutations in Pituitary Cushing Adenomas—Targeted Analysis by Next-Generation SequencingSemantic proximity Read ↗

Analysis of Potential RNA Biomarkers Expression in Corticotroph Pituitary Neuroendocrine TumoursSemantic proximity Read ↗

Molecular characterization of archival adrenal tumor tissue from patients with ACTH-independent Cushing syndrome.Semantic proximity Read ↗

USP8 and TP53 Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors.Semantic proximity Read ↗

Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive CorticotrophinomasSemantic proximity Read ↗

Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors.Semantic proximity Read ↗

TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome.Semantic proximity Read ↗

PATHOGENESIS OF CUSHING DISEASE: AN UPDATE ON THE GENETICS OF CORTICOTROPINOMAS.Semantic proximity Read ↗

USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour statusSemantic proximity Read ↗

Clinical Spectrum of USP8 Pathogenic Variants in Cushing's DiseaseSemantic proximity Read ↗

Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.