Article
USP8 and TP53 Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors.
The Journal of clinical endocrinology and metabolism - 8 Mar 2021
Uzilov Andrew V, Taik Patricia, Cheesman Khadeen C, Javanmard Pedram, Ying Kai, Roehnelt Alessia, Wang Huan, Fink Marc Y, Lau Chun Yee, Moe Aye S, Villar Joaquin, Bederson Joshua B, Stewart Andrew F, Donovan Michael J, Mahajan Milind, Sebra Robert, Post Kalmon D, Chen Rong, Geer Eliza B
Abstract excerpt
CONTEXT: Pituitary corticotroph adenomas are rare tumors that can be associated with excess adrenocorticotropin (ACTH) and adrenal cortisol production, resulting in the clinically debilitating endocrine condition Cushing disease. A subset of corticotroph tumors behave aggressively, and genomic drivers behind the development of these tumors are largely unknown. OBJECTIVE: To investigate genomic drivers of...
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