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Article

USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status

3 Oct 2019

Abstract excerpt

OBJECTIVE: Pituitary corticotroph adenomas commonly cause Cushing's disease (CD) but part of these tumours are hormonally inactive (silent corticotroph adenomas, SCA). USP8 mutations are well-known driver mutations in corticotrophinomas. Differences in transcriptomic profiles between functioning and silent tumours or tumours with different USP8 status have not been investigated. DESIGN AND METHODS: Forty-eight...

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PMID: 31581124
DOI: 10.1530/eje-19-0194

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