Article
SARS-CoV-2 intra-host recombination promotes epistatic spike interactions and temperature-dependent adaptation.
Cell reports - 23 Jun 2026
Altaf Mazharul, Kin Cheng Mark Tsz, González-Vázquez Luis Daniel, Castin Jesu, Kemp Steven A, Hisner Ryan, Martin Darren P, Thukral Lipi, Meng Bo, Gupta Ravindra K
Abstract excerpt
Prolonged infections in immunocompromized individuals are associated with accumulation of unexpected combinations of mutations, as exemplified by the Omicron variant. Here, we show that intra-host evolution during a chronic SARS-CoV-2 infection in the pre-Omicron era was associated with mutations that modulate antibody evasion, cell entry efficiency, spike processing, and fusogenicity. Single spike N-terminal...
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