Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects.

mBio - 29 Jun 2021

Rocheleau Lynda, Laroche Geneviève, Fu Kathy, Stewart Corina M, Mohamud Abdulhamid O, Côté Marceline, Giguère Patrick M, Langlois Marc-André, Pelchat Martin

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that is continuously evolving. Although its RNA-dependent RNA polymerase exhibits some exonuclease proofreading activity, viral sequence diversity can be produced by replication errors and host factors. A diversity of genetic variants can be observed in the intrahost viral population structure of infected individuals. Most mutations will...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Giant Cells

Share to HEK293 Cells

Share to High-Throughput Nucleotide Sequencing

Share to Mutation Rate

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 34182784
DOI: 10.1128/mBio.00788-21
PMCID: PMC8262852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects.PMID 34182784Read ↗

Identification of a High-frequency Intra-host SARS-CoV-2 spike Variant with Enhanced Cytopathic and Fusogenic EffectSemantic proximity Read ↗

Intra-host evolution provides for continuous emergence of SARS-CoV-2 variantsSemantic proximity Read ↗

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolatesSemantic proximity Read ↗

Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates.Semantic proximity Read ↗

SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants.Semantic proximity Read ↗

Intra-Host Evolution Provides for the Continuous Emergence of SARS-CoV-2 Variants.Semantic proximity Read ↗

SARS-CoV-2 Variants of Concern Have Acquired Mutations Associated With an Increased Spike CleavageSemantic proximity Read ↗

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.Semantic proximity Read ↗

Intrahost evolution leading to distinct lineages in the upper and lower respiratory tracts during SARS-CoV-2 prolonged infectionSemantic proximity Read ↗

SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection.Semantic proximity Read ↗

Convergent Evolution and Host-Limiting Impacts of SARS-CoV-2 Revealed by Cellular Experiments.Semantic proximity Read ↗

SARS-CoV-2 intra-host recombination promotes epistatic spike interactions and temperature-dependent adaptation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.