Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of splenectomy on skin inflammation and psoriasis-like phenotype of imiquimod-treated mice.

Scientific reports - 30 Aug 2022

Shinno-Hashimoto Hiroyo, Eguchi Akifumi, Sakamoto Akemi, Wan Xiayun, Hashimoto Yaeko, Fujita Yuko, Mori Chisato, Hatano Masahiko, Matsue Hiroyuki, Hashimoto Kenji

Abstract excerpt

Imiquimod (IMQ) is widely used as animal model of psoriasis, a chronic inflammatory skin disorder. Although topical application of IMQ to back skin causes splenomegaly in mice, how the spleen affects the psoriasis-like phenotype of IMQ-treated mice remains unclear. In this study, we analyzed the cellular composition of spleen and measured metabolites in blood of IMQ-treated mice. We also investigated whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatitis
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammation

Share to Mice, Inbred BALB C

Share to Psoriasis

Share to Splenectomy

Share to Splenomegaly

Source

Open in PubMed Open full text

Identifiers

PMID: 36042262
DOI: 10.1038/s41598-022-18900-7
PMCID: PMC9427736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of splenectomy on skin inflammation and psoriasis-like phenotype of imiquimod-treated mice.PMID 36042262Read ↗

Single-Cell RNA Sequencing Reveals the Immune Cell Profiling in IMQ Induced Psoriasis-Like ModelSemantic proximity Read ↗

CD169+ Skin Macrophages Function as a Specialized Subpopulation in Promoting Psoriasis-like Skin Disease in MiceSemantic proximity Read ↗

Imiquimod-induced psoriasis model: induction protocols, model characterization and factors adversely affecting the modelSemantic proximity Read ↗

Allicin Ameliorates IMQ-induced psoriasis-like Skin Inflammation Via Disturbing the Interaction of Keratinocytes with IL-17ASemantic proximity Read ↗

Identification of Key Genes Related to Immune-Lipid Metabolism in Skin Barrier Damage and Analysis of Immune InfiltrationSemantic proximity Read ↗

Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of PsoriasisSemantic proximity Read ↗

LiangxueJiedu Formula improves psoriatic dermatitis by regulating the circadian clock to inhibit IL-17-producing Th17 and γδT cellsSemantic proximity Read ↗

Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretomeSemantic proximity Read ↗

Isostearic acid is an active component of imiquimod formulations 2 used to induce psoriaform disease modelsSemantic proximity Read ↗

Study of dietary‑induced progression of psoriasis‑like mice based on gut macrophage polarizationSemantic proximity Read ↗

Indigo alleviates psoriasis through the AhR/NF-κB signaling pathway: an in vitro and in vivo studySemantic proximity Read ↗

PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated ConditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.