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Article

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.

Cell - 19 Apr 2018

Hofweber Mario, Hutten Saskia, Bourgeois Benjamin, Spreitzer Emil, Niedner-Boblenz Annika, Schifferer Martina, Ruepp Marc-David, Simons Mikael, Niessing Dierk, Madl Tobias, Dormann Dorothee

Abstract excerpt

Cytoplasmic FUS aggregates are a pathological hallmark in a subset of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). A key step that is disrupted in these patients is nuclear import of FUS mediated by the import receptor Transportin/Karyopherin-β2. In ALS-FUS patients, this is caused by mutations in the nuclear localization signal (NLS) of FUS that weaken Transportin binding....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29677514
DOI: 10.1016/j.cell.2018.03.004

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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