Article

FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation

2020-09-14

Abstract excerpt

<h4>Summary</h4> Mutations in the RNA binding protein (RBP) FUS cause amyotrophic lateral sclerosis (ALS) and result in its nuclear depletion and cytoplasmic mislocalisation, with cytoplasmic gain of function thought to be crucial in pathogenesis. Here, we show that expression of mutant FUS at physiological levels drives translation inhibition in both mouse and human motor neurons. Rather than acting directly on...

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Literature Corpus work: 02a411e5-4b5b-57ae-b0fd-e8378ef1e661
DOI: 10.1101/2020.09.14.296038

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