Article
Poorly perfused tumor regions harbor T cells with a glucose-dependent effector phenotype.
EMBO reports - 1 Jun 2026
Riera-Borrull Marta, Cerdán Porqueras Víctor, Tejedor Vaquero Sonia, Tomaselli González Claudia, Guzmán Mauricio, Martinuzzi Donata, Ceacero-Heras Diego, Cerutti Andrea, Aramburu Jose, López-Rodríguez Cristina
Abstract excerpt
Effector T lymphocytes are avid nutrient consumers, but can function in nutrient-poor tumor microenvironments. Availability of key nutrients such as glucose inside the tumor is not homogeneous, and how tumor-infiltrating T lymphocytes (TILs) differ between regions with better and poorer blood perfusion is not well known. Here we show that in vitro-stimulated TILs can induce substantial production of hallmark...
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