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Article

Manipulation of metabolic pathways to promote stem-like and memory T cell phenotypes for immunotherapy.

Frontiers in immunology - 1 Jan 2022

Claiborne Michael D

Abstract excerpt

Utilizing the immune system's capacity to recognize and kill tumor cells has revolutionized cancer therapy in recent decades. Phenotypic study of antitumor T cells supports the principle that superior tumor control is achieved by cells with more long-lived memory or stem-like properties as compared to terminally differentiated effector cells. In this Mini-Review, we explore recent advances in profiling the...

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Identifiers

PMID: 36741362
DOI: 10.3389/fimmu.2022.1061411
PMCID: PMC9889361

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