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Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.

PloS one - 1 Jan 2015

Ali Asho, Hasan Zahra, McNerney Ruth, Mallard Kim, Hill-Cawthorne Grant, Coll Francesc, Nair Mridul, Pain Arnab, Clark Taane G, Hasan Rumina

Abstract excerpt

Improved molecular diagnostic methods for detection drug resistance in Mycobacterium tuberculosis (MTB) strains are required. Resistance to first- and second- line anti-tuberculous drugs has been associated with single nucleotide polymorphisms (SNPs) in particular genes. However, these SNPs can vary between MTB lineages therefore local data is required to describe different strain populations. We used whole...

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Identifiers

PMID: 25719196
DOI: 10.1371/journal.pone.0117771
PMCID: PMC4342168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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