Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis.

Hippocampus - 1 Apr 2023

Lee Hyunah, Price Jack, Srivastava Deepak P, Thuret Sandrine

Abstract excerpt

Hippocampal neurogenesis (HN) is considered an important mechanism underlying lifelong brain plasticity, and alterations in this process have been implicated in early Alzheimer's disease progression. APOE polymorphism is the most common genetic risk factor for late-onset Alzheimer's disease where the ε4 genotype is associated with a significantly earlier disease onset compared to the neutral ε3 allele. Recently,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Genotype

Share to Hippocampus

Share to Neurogenesis

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 36709412
DOI: 10.1002/hipo.23502
PMCID: PMC10947111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis.PMID 36709412Read ↗

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.Semantic proximity Read ↗

APOE4 Alters Early Transcriptional Programs and Inflammatory Signaling in Human Induced Pluripotent Stem Cells.Semantic proximity Read ↗

Apolipoprotein E (APOE) expression pattern in human induced pluripotent stem cells during in vitro neural induction.Semantic proximity Read ↗

Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: pathophysiological relevance for Alzheimer's disease?Semantic proximity Read ↗

Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles.Semantic proximity Read ↗

Apolipoprotein E expression pattern in human induced pluripotent stem cells during in vitro neural inductionSemantic proximity Read ↗

<i>APOE</i> deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoidsSemantic proximity Read ↗

Cholesterol and matrisome pathways dysregulated in human <i>APOE</i> ε4 gliaSemantic proximity Read ↗

Investigating the role of APOE: limitations of human pluripotent stem cell-derived cerebral organoidsSemantic proximity Read ↗

Integration-free induced pluripotent stem cell line derived from a 62-years-old male donor with APOE-epsilon4/epsilon4 alleles.Semantic proximity Read ↗

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease RiskSemantic proximity Read ↗

ApoE is required for maintenance of the dentate gyrus neural progenitor pool.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.