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Article

Unveiling a novel role for p19Arf (alternative reading frame) in mESC differentiation toward the pancreatic lineage.

Scientific reports - 26 May 2026

Elena De Marino, Giuliana Napolitano, Giuseppina Roscigno, Valeria Lucci, Geppino Falco, Viola Calabrò, Maria Vivo, Tiziana Angrisano, Dario Antonini, Alessandra Pollice

Abstract excerpt

The tumor suppressor ARF (p14 in human, p19 in mouse), has traditionally been characterized by its pivotal role in tumor surveillance. However, its involvement in an expanding range of cellular processes reveals that its functions are broader and more complex than initially appreciated. Here, we uncover a previously unrecognized role of p19ARF in endodermal differentiation, specifically in pancreatic lineage...

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Identifiers

PMID: 42192133
DOI: 10.1038/s41598-026-53355-0
PMCID: PMC13439060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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