Unveiling a novel role for p19Arf (alternative reading frame) in mESC differentiation toward the pancreatic lineage.

Abstract excerpt

The tumor suppressor ARF (p14 in human, p19 in mouse), has traditionally been characterized by its pivotal role in tumor surveillance. However, its involvement in an expanding range of cellular processes reveals that its functions are broader and more complex than initially appreciated. Here, we...

Topics

• Animals
• Cell Differentiation
• Mice
• Cyclin-Dependent Kinase Inhibitor p16
• Endoderm
• Mouse Embryonic Stem Cells
• Pancreas
• Cell Lineage
• Gene Expression Profiling
• CRISPR-Cas Systems
• Mutation