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Article

Cell Lineage Infidelity in PDAC Progression and Therapy Resistance

2 Dec 2021

Abstract excerpt

Infidelity to cell fate occurs when differentiated cells lose their original identity and either revert to a more multipotent state or transdifferentiate into a different cell type, either within the same embryonic lineage or in an entirely different one. Whilst in certain circumstances, such as in wound repair, this process is beneficial, it can be hijacked by cancer cells to drive disease initiation and...

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PMID: 34926472
DOI: 10.3389/fcell.2021.795251

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