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Article

Allosteric network of dynamic coupling within BAP1-UCH revealed by methyl NMR.

Nature communications - 26 May 2026

Lai Chih-Hsuan, Lou Yuan-Chao, Chang Chi-Fon, Lu Wei-Lin, Sriramoju Manoj Kumar, Wang Yong-Sheng, Wu Kuen-Phon, Camilloni Carlo, Hsu Shang-Te Danny

Abstract excerpt

BRCA1-associated protein 1 (BAP1) is a tumor suppressor whose deubiquitinase (DUB) activity is essential for transcriptional regulation and is frequently compromised in cancer by mutations clustered in its ubiquitin carboxyl-terminal hydrolase (UCH) domain. The structural and dynamic bases of these oncogenic mutations remain elusive. Here, we introduce 22 cancer mutations and additional methyl mutations on the...

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Identifiers

PMID: 42191708
DOI: 10.1038/s41467-026-73600-4
PMCID: PMC13388669

Genes

BAP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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