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Article

Insights into mechanisms of MALT1 allostery from NMR and AlphaFold dynamic analyses.

Communications biology - 16 Jul 2024

Wallerstein Johan, Han Xiao, Levkovets Maria, Lesovoy Dmitry, Malmodin Daniel, Mirabello Claudio, Wallner Björn, Sun Renhua, Sandalova Tatyana, Agback Peter, Karlsson Göran, Achour Adnane, Agback Tatiana, Orekhov Vladislav

Abstract excerpt

Mucosa-associated lymphoid tissue lymphoma-translocation protein 1 (MALT1) is an attractive target for the development of modulatory compounds in the treatment of lymphoma and other cancers. While the three-dimensional structure of MALT1 has been previously determined through X-ray analysis, its dynamic behaviour in solution has remained unexplored. We present here dynamic analyses of the apo MALT1 form along...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39014105
DOI: 10.1038/s42003-024-06558-y
PMCID: PMC11252132

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