Article

Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

2020-05-06

Abstract excerpt

Here, we used for the first time Hydrogen-Deuterium eXchange coupled to Mass Spectrometry (HDX-MS) to investigate conformational differences between the human standard 20S (std20S) and immuno 20S (i20s) proteasomes alone or in complex with PA28αβ or PA28γ activators. Their solvent accessibility was analyzed through a dedicated bioinformatic pipeline including stringent statistical analysis and 3D visualization. Th...

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Literature Corpus work: b2728472-03dd-52f7-8a1a-a9e7a60491c5
DOI: 10.1101/2020.05.05.078170

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