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Article

Impacts of Cancer-associated Mutations on the Structure-Activity Relationship of BAP1.

Journal of molecular biology - 15 May 2022

Puri Sarita, Chen Szu-Ni, Chiu Yi-Hsiang, Draczkowski Piotr, Ko Kuang-Ting, Yang Tzu-Jing, Wang Yong-Sheng, Uchiyama Susumu, Hsu Shang-Te Danny

Abstract excerpt

BRAC1 associated protein-1 (BAP1) is a major tumor suppressor involved in many cancers. The deubiquitinase (DUB) activity of BAP1 is essential for its nuclear localization, histone remodeling and proteostasis associated with mitochondrial calcium flux. Loss of the DUB activity due to catalytic mutations within the ubiquitin C-terminal hydrolase (UCH) domain of BAP1 (BAP1-UCH) directly contributes to oncogenesis....

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Identifiers

PMID: 35317997
DOI: 10.1016/j.jmb.2022.167553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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