Article

Identification of osteopontin as a positional and functional candidate gene for cardiac hypertrophy in the SHRSP rat

2026-08-27

Abstract excerpt

Left ventricular hypertrophy, common in cardiometabolic and renal disease, is a major risk factor for cardiovascular morbidity and mortality. Left ventricular mass is a highly heritable, polygenic trait. Linkage studies in WKY and SHRSP rats have identified a quantitative trait locus for left ventricular mass index on chromosome 14. Congenic strains, where trait-associated genetic loci are introduced into a contro...

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Literature Corpus work: 70073564-dbd8-546f-a66c-9a8a80a59474
DOI: 10.64898/2026.08.24.746886

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