Article

Hypoplastic left heart syndrome cardiomyocytes exhibit intrinsic stress vulnerabilities and augmented stress responses in vitro

2025-12-04

Abstract excerpt

<title>Abstract</title> <p>Background Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect characterised by underdevelopment of left-sided cardiac structures. While genetic predisposition contributes to HLHS, the relevance of environmental stressors is increasingly recognised, yet the cellular mechanisms linking genetic susceptibility to environmental vulnerability remain unclear. We aimed t...

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Literature Corpus work: c69fb910-7b46-5906-b106-b52ad4b36da5
DOI: 10.21203/rs.3.rs-8250379/v1

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