Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential genetic mutations impair DNA damage repair and modulate tumor immune microenvironment in ccRCC.

MedScience - 1 Apr 2026

He Hongchao, Liu Xian-De, Jonasch Eric

Abstract excerpt

Targeting DNA repair defects has shown therapeutic benefits in solid tumors with genetic mutations that disrupt DNA damage repair (DDR) pathways. Clear cell renal cell carcinoma (ccRCC) demonstrates an intermediate level of genomic instability, while it rarely carries mutations in these genes. Instead, it is characterized by the loss of chromosome 3p, the von Hippel-Lindau (VHL) tumor suppressor gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to DNA Damage
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PBRM1 gene

Share to SETD2 gene

Share to Kidney Neoplasms

Share to Mutation

Share to Tumor Microenvironment

Source

Identifiers

PMID: 42189393
DOI: 10.1007/s11684-025-1136-4

Genes

BAP1
PBRM1
SET
SETD2
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential genetic mutations impair DNA damage repair and modulate tumor immune microenvironment in ccRCC.PMID 42189393Read ↗

PBRM1, SETD2 and BAP1 - the trinity of 3p in clear cell renal cell carcinoma.Semantic proximity Read ↗

DNA damage response alterations in clear cell renal cell carcinoma: clinical, molecular, and prognostic implications.Semantic proximity Read ↗

Clear cell renal cell carcinoma ontogeny and mechanisms of lethality.Semantic proximity Read ↗

Genomic characterization of clear cell renal cell carcinoma using targeted gene sequencingSemantic proximity Read ↗

Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

DNA damage repair pathway alterations in metastatic clear cell renal cell carcinoma and implications on systemic therapySemantic proximity Read ↗

ATR and BRCA2 Simultaneous Mutation in a ccRCC With Sarcomatoid Differentiation and Extensive Metastases: A Case Report.Semantic proximity Read ↗

Molecular pathways in renal cell carcinomaSemantic proximity Read ↗

Molecular genetics of clear-cell renal cell carcinoma.Semantic proximity Read ↗

BAP1, PBRM1 and SETD2 in clear-cell renal cell carcinoma: molecular diagnostics and possible targets for personalized therapies.Semantic proximity Read ↗

Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma.Semantic proximity Read ↗

PRMT1 is a critical dependency in clear cell renal cell carcinoma through its role in post-transcriptional regulation of DNA damage response genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.