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DNA damage repair pathway alterations in metastatic clear cell renal cell carcinoma and implications on systemic therapy

1 Jun 2020

Abstract excerpt

BACKGROUND: Loss-of-function alterations in DNA damage repair (DDR) genes are associated with human tumorigenesis and may determine benefit from immune-oncology (I/O) agents as shown in colon cancer. However, biologic significance and relevance to I/O in metastatic clear cell RCC (ccRCC) are unknown. METHODS: Genomic data and treatment outcomes were retrospectively collected for patients with metastatic ccRCC....

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PMID: 32571992
DOI: 10.1136/jitc-2019-000230

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