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Article

Molecular genetics of clear-cell renal cell carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2014

Brugarolas James

Abstract excerpt

Renal cell carcinoma of clear-cell type (ccRCC) is an enigmatic tumor type, characterized by frequent inactivation of the VHL gene (infrequently mutated in other tumor types), responsiveness to angiogenesis inhibitors, and resistance to both chemotherapy and conventional radiation therapy. ccRCC tumors exhibit substantial mutation heterogeneity. Recent studies using massively parallel sequencing technologies have...

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Source

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Identifiers

PMID: 24821879
DOI: 10.1200/JCO.2012.45.2003
PMCID: PMC4050206

Genes

VHL
BAP1
PBRM1
TSC1
MTOR
PTEN
SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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