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Article

DNA damage response alterations in clear cell renal cell carcinoma: clinical, molecular, and prognostic implications.

European journal of medical research - 7 Feb 2024

Jing Xiao, Qin Xiangcheng, Liu Hao, Liu Huanhuan, Wang Huina, Qin Jiayue, Zhang Yanui, Cao Shanbo, Fan Xiaodong

Abstract excerpt

BACKGROUND: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic responses. Nonetheless, the characteristics and significance of DDR alterations in clear cell renal cell carcinoma (ccRCC) remain undefined. This study aimed to explore the predictive role, molecular mechanism, and tumor immune profile of DDR genes in ccRCC. METHODS: We prospectively sequenced 757 tumors and matched...

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Share to Cancer Immunotherapy and Biomarkers
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38326910
DOI: 10.1186/s40001-024-01678-x
PMCID: PMC10848511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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