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ATR and BRCA2 Simultaneous Mutation in a ccRCC With Sarcomatoid Differentiation and Extensive Metastases: A Case Report.

Urology - 1 Aug 2021

Yang Jing, Wang Junyun, Liang Yunshi, Wang Jianfei, Hsu Jin, Liu Guorong, Li Xiubo, Tang Zhaoliang, Zhang Jinxiang, Huang Yunhai, Yuan Hong, Chen Yehui

Abstract excerpt

The genomic landscape and driver-gene mutations differ significantly among diverse histological subtypes of clear cell renal cell carcinoma (ccRCC) due to the intratumoral heterogeneity. Frequent mutations in canonical DNA damage response genes, such as BRCA1/2 or ATR serine/threonine kinase (ATR) haven't been reported even in large-scale genomic profiling of ccRCC researches. Herein, we reported a rare ccRCC...

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PMID: 33961890
DOI: 10.1016/j.urology.2021.04.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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