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Article

Structural Basis for Potassium Inhibition of WNK Kinases.

Biochemistry - 16 Jun 2026

Goldsmith Elizabeth J, Pleinis John M, Wagner Armin, Mykhaylyk Vitaliy, Akella Radha, Humphreys John M, He Haixia, Norrell Logan, Morrison Daryl E, Rodan Aylin R

Abstract excerpt

WNK kinases are chloride- and osmotic-stress-regulated protein kinases recently shown to be controlled by potassium. Prior studies demonstrated the direct binding of chloride and osmotic stress-related water in WNK kinase regulation. Here, we probe potassium binding and regulation of WNK kinases via crystallography coupled with mutagenic analysis of WNK kinase autophosphorylation and activity. Crystals of...

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Topics

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Share to Chlorides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to WNK Lysine-Deficient Protein Kinase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 42186973
DOI: 10.1021/acs.biochem.5c00825
PMCID: PMC13397483

Genes

WNK1
WNK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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