Article
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2008
Ponce-Coria José, San-Cristobal Pedro, Kahle Kristopher T, Vazquez Norma, Pacheco-Alvarez Diana, de Los Heros Paola, Juárez Patricia, Muñoz Eva, Michel Gabriela, Bobadilla Norma A, Gimenez Ignacio, Lifton Richard P, Hebert Steven C, Gamba Gerardo
Abstract excerpt
The Na(+):K(+):2Cl(-) cotransporter (NKCC2) is the target of loop diuretics and is mutated in Bartter's syndrome, a heterogeneous autosomal recessive disease that impairs salt reabsorption in the kidney's thick ascending limb (TAL). Despite the importance of this cation/chloride cotransporter (CC...
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