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Article

Characterization of the kinase activity of a WNK4 protein complex.

American journal of physiology. Renal physiology - 1 Sept 2009

Ahlstrom Robert, Yu Alan S L

Abstract excerpt

Mutations in WNK4 protein kinase cause pseudohypoaldosteronism type II (PHAII), a genetic disorder that is characterized by renal NaCl and K(+) retention leading to hypertension and hyperkalemia. Consistent with this, WNK4 is known to regulate several renal tubule transporters, including the NaCl cotransporter, NCC, and the K(+) channel, ROMK, but the mechanisms are incompletely understood, and the role of the...

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Source

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Identifiers

PMID: 19587141
DOI: 10.1152/ajprenal.00358.2009
PMCID: PMC2739714

Genes

WNK4
OSR1

Provenance

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Related research

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Characterization of the kinase activity of a WNK4 protein complex.PMID 19587141Read ↗

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WNKs: protein kinases with a unique kinase domain.Semantic proximity Read ↗

WNK kinases and the kidney.Semantic proximity Read ↗

Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.Semantic proximity Read ↗

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