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Article

Ancestry-informative regulatory variants at KCNB1 modulate adipogenesis and body mass index.

Frontiers in endocrinology - 1 Jan 2026

Teixeira Samantha Kuwada, Laurindo Caroline Pancera, Sato Fábio Takeo, Zuleta Luiz Fernando Goda, Duarte Nubia E, Jensen Ana Vitória V, Paço Samantha L G, Pereira Alexandre C, Sakabe Noboru, Nobrega Marcelo, Krieger Jose Eduardo

Abstract excerpt

Introduction: Obesity and related metabolic disorders represent a major global health burden, yet their genetic determinants remain incompletely characterized, particularly in non-European populations. We aimed to identify body mass index (BMI)-associated loci in an admixed Brazilian population and to functionally characterize ancestry-enriched variants contributing to obesity risk. Methods: We conducted a...

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Identifiers

PMID: 42181176
DOI: 10.3389/fendo.2026.1805824
PMCID: PMC13189953

Genes

KCNB1

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