Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

doi:10.1038/s41366-021-00761-1

Article

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

International journal of obesity (2005) - 1 May 2021

Scliar Marilia O, Sant'Anna Hanaisa P, Santolalla Meddly L, Leal Thiago P, Araújo Nathalia M, Alvim Isabela, Borda Victor, Magalhães Wagner C S, Gouveia Mateus H, Lyra Ricardo, Machado Moara, Michelin Lucas, Rodrigues Maíra R, Araújo Gilderlanio S, Kehdy Fernanda S G, Zolini Camila, Peixoto Sérgio V, Luizon Marcelo R, Lobo Francisco, Naslavsky Michel S, Yamamoto Guilherme L, Duarte Yeda A O, Hansen Matthew E B, Norris Shane A, Gilman Robert H, Guio Heinner, Hsing Ann W, Mbulaiteye Sam M, Mensah James, Dutil Julie, Yeager Meredith, Yeboah Edward, Tishkoff Sarah A, Choudhury Ananyo, Ramsay Michele, Passos-Bueno Maria Rita, Zatz Mayana, O Connor Timothy D, Pereira Alexandre C, Barreto Mauricio L, Lima-Costa Maria Fernanda, Horta Bernardo L, Tarazona-Santos Eduardo

Abstract excerpt

BACKGROUND/OBJECTIVES: Admixed populations are a resource to study the global genetic architecture of complex phenotypes, which is critical, considering that non-European populations are severely underrepresented in genomic studies. Here, we study the genetic architecture of BMI in children, young adults, and elderly individuals from the admixed population of Brazil. SUBJECTS/METHODS: Leveraging admixture in...

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Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

Abstract excerpt

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