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Article

Identification of breakpoint regions and single nucleotide variations of RHD hybrid alleles by long-read sequencing.

Vox sanguinis - 1 Aug 2026

Chang Ti-Cheng, Yu Jing, Ju Bensheng, Kim Teha, Loyd Melanie, Ridout Granger, Neale Geoffrey, Hankins Jane S, Weiss Mitchell J, Ochoa Gorka, Vege Sunitha, Chou Stella T, Easton John, Zheng Yan

Abstract excerpt

BACKGROUND AND OBJECTIVES: RHD*03N.01 (RHD*DIIIa-CEVS(4-7)-D) and RHD*01N.06(RHD*D-CEVS(4-7)-D) are hybrid alleles that encode a partial C antigen, resulting in increased risk of C alloimmunization in individuals without a conventional C antigen. As detection of the hybrid alleles remains challenging, new markers can aid accurate identification, ensuring provision of C-negative blood to individuals at risk....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42179021
DOI: 10.1111/vox.70292
PMCID: PMC13453920

Genes

RHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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