Article
Evaluation of targeted exome sequencing for 28 protein-based blood group systems, including the homologous gene systems, for blood group genotyping.
Transfusion - 1 Apr 2017
Schoeman Elizna M, Lopez Genghis H, McGowan Eunike C, Millard Glenda M, O'Brien Helen, Roulis Eileen V, Liew Yew-Wah, Martin Jacqueline R, McGrath Kelli A, Powley Tanya, Flower Robert L, Hyland Catherine A
Abstract excerpt
BACKGROUND: Blood group single nucleotide polymorphism genotyping probes for a limited range of polymorphisms. This study investigated whether massively parallel sequencing (also known as next-generation sequencing), with a targeted exome strategy, provides an extended blood group genotype and the extent to which massively parallel sequencing correctly genotypes in homologous gene systems, such as RH and MNS....
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