Article
Overcoming the challenges of interpreting complex and uncommon RH alleles from whole genomes.
Vox sanguinis - 1 Nov 2020
Halls Justin B L, Vege Sunitha, Simmons Daimon P, Aeschlimann Judith, Bujiriri Baderha, Mah Helen H, Lebo Matthew S, Vijay Kumar Prathik K, Westhoff Connie M, Lane William J
Abstract excerpt
BACKGROUND AND OBJECTIVES: Rh is one of the most diverse and complex blood group systems. Recently, next generation sequencing (NGS) has proven to be a viable option for RH genotyping. We have developed automated software (bloodTyper) for determining alleles encoding RBC antigens from NGS-based whole genome sequencing (WGS). The bloodTyper algorithm has not yet been optimized and evaluated for complex and...
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