Article
From the investigation of RHD-CE hybrid genes to the recognition of RHCE variants and RHD zygosity. Expanding the analysis by QMPSF in Brazilian donors and in patients with sickle cell disease.
Blood transfusion = Trasfusione del sangue - 1 May 2023
de Paula Vendrame Tatiane A, Arnoni Carine P, Latini Flavia R M, Pereira Cortez Afonso J, Bénech Caroline, Fichou Yann, Castilho Lilian
Abstract excerpt
BACKGROUND: Hybrid genes are responsible for the formation of Rh variants and are common in patients with sickle cell disease (SCD). However, it is not usually possible to detect them by conventional molecular protocols. In the present study, hybrid genes were investigated using the Quantitative Multiplex Polymerase chain reaction of Short Fluorescent Fragments (QMPSF), a molecular protocol that quantifies the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.