Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic characterization of the RH locus detects complex and novel structural variation in multi-ethnic cohorts.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2019

Wheeler Marsha M, Lannert Kerry W, Huston Haley, Fletcher Shelley N, Harris Samantha, Teramura Gayle, Maki Helena J, Frazar Chris, Underwood Jason G, Shaffer Tristan, Correa Adolfo, Delaney Meghan, Reiner Alex P, Wilson James G, Nickerson Deborah A, Johnsen Jill M

Abstract excerpt

PURPOSE: Rh antigens can provoke severe alloimmune reactions, particularly in high-risk transfusion contexts, such as sickle cell disease. Rh antigens are encoded by the paralogs, RHD and RHCE, located in one of the most complex genetic loci. Our goal was to characterize RH genetic variation in multi-ethnic cohorts, with the focus on detecting RH structural variation (SV). METHODS: We customized analytical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to Black or African American

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Ethnicity

Share to Genomic Structural Variation

Share to Indians, North American

Share to Rh-Hr Blood-Group System

Share to World Health Organization

Source

Open in PubMed Open full text

Identifiers

PMID: 29955105
DOI: 10.1038/s41436-018-0074-9
PMCID: PMC6311147

Genes

RHCE
RHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic characterization of the RH locus detects complex and novel structural variation in multi-ethnic cohorts.PMID 29955105Read ↗

A novel algorithm comprehensively characterizes human RH genes using whole-genome sequencing data.Semantic proximity Read ↗

Overcoming the challenges of interpreting complex and uncommon RH alleles from whole genomes.Semantic proximity Read ↗

Allelic Cataloging of RHD-RHCE Reference Sequences Using Targeted Long-Read Sequencing.Semantic proximity Read ↗

Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease.Semantic proximity Read ↗

Identification of six new RHCE variant alleles in individuals of diverse racial origin.Semantic proximity Read ↗

Evaluation of targeted exome sequencing for 28 protein-based blood group systems, including the homologous gene systems, for blood group genotyping.Semantic proximity Read ↗

Resolving RH and GYP hybrid alleles while accessing the entire blood group genome with Nanopore adaptive samplingSemantic proximity Read ↗

The role of genomics in transfusion medicine.Semantic proximity Read ↗

Five-Years Review of RHCE Alleles Detected after Weak and/or Discrepant C Results in Southern France.Semantic proximity Read ↗

Machine learning to optimize automated RH genotyping using whole-exome sequencing data.Semantic proximity Read ↗

Rhesus blood group haplotype determination by nanopore sequencing and adaptive sampling enables the precise determination of complex allele combinations that could not be accurately determined by standard methods.Semantic proximity Read ↗

Systematic RH genotyping and variant identification in French donors of African origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.