Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

doi:10.1038/s41467-026-73122-z

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Article

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

Nature communications - 25 May 2026

Tyrmi Jaakko S, Karjalainen Juha, Venkatesh Samvida S, Benoit-Pilven Clara, Lemmelä Susanna M, Brunak Søren, Aagaard Bitten, Bruun Mie T, Erikstrup Christian, Ullum Henrik, Pedersen Ole B, Banasik Karina, Sørensen Erik, Mikkelsen Christina, Schwinn Michael, Sturluson Arni, Ostrowski Sisse R, Kettunen Johannes, Nielsen Henriette Svarre, Nyegaard Mette, Westergaard David, Rafnar Thorunn, Sulem Patrick, Stefansson Kari, Palta Priit, Laisk Triin, Tukiainen Taru, Lindgren Cecilia M, Daly Mark, Havulinna Aki S, Laivuori Hannele M

Abstract excerpt

Intrahepatic cholestasis of pregnancy, which affects 0.2-2% of pregnancies, is characterized by pruritus, increased aminotransferase activity and elevated serum bile acids. Previous studies have implicated liver-enriched genes in intrahepatic cholestasis of pregnancy. We conducted a meta-analysis of intrahepatic cholestasis of pregnancy genome-wide association studies in the FinnGen study, deCODE, Estonian...

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PMID: 42178310
DOI: 10.1038/s41467-026-73122-z
PMCID: PMC13385924

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