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Article

Genetic issues in ICP

26 Jul 2024

Abstract excerpt

Intrahepatic cholestasis of pregnancy (ICP) is the commonest gestational liver disorder with variable global incidence. Genetic susceptibility, combined with hormonal and environmental influences, contributes to ICP aetiology. Adverse pregnancy outcomes linked to elevated serum bile acids highlight the importance of comprehensive risk assessment. ABCB4 and ABCB11 gene variants play a significant role in about 20%...

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PMID: 39262913
DOI: 10.1177/1753495x241263441

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