Article
The pathophysiology of intrahepatic cholestasis of pregnancy.
Clinics and research in hepatology and gastroenterology - 1 Apr 2016
Dixon Peter H, Williamson Catherine
Abstract excerpt
A number of liver disorders are specific to pregnancy. Amongst these, intrahepatic cholestasis of pregnancy (ICP), also known as obstetric cholestasis (OC), is the commonest, affecting approximately 1 in 140 UK pregnancies. Patients commonly present in the third trimester with severe pruritus and deranged serum liver tests; bile acids are elevated, in severe cases >40 μmol/L. Although the disease is considered...
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