Article
Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation.
BMC medical genomics - 7 Jul 2014
Du QiaoLing, Pan YouDong, Zhang YouHua, Zhang HaiLong, Zheng YaJuan, Lu Ling, Wang JunLei, Duan Tao, Chen JianFeng
Abstract excerpt
BACKGROUND: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease with potentially deleterious consequences for the fetus, particularly when maternal serum bile-acid concentration >40 μM. However, the etiology and pathogenesis of ICP remain elusive. To reveal the underlying molecular mechanisms for the association of maternal serum bile-acid level and fetal outcome in ICP patients,...
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